Frontiers in Public Health - Expert Survey on 100 Days Mission

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Tangentially relevant to AI safety through the lens of global catastrophic biological risk; the 100 Days Mission framework intersects with AI-assisted pathogen surveillance and response coordination discussions in biosecurity-adjacent AI governance work.

Metadata

Importance: 28/100journal articleanalysis

Summary

This Frontiers in Public Health article presents findings from an expert survey evaluating the feasibility and priorities of the '100 Days Mission'—a global health security initiative aiming to develop vaccines, therapeutics, and diagnostics within 100 days of a pandemic threat being identified. The survey captures expert consensus on key bottlenecks, governance challenges, and technical requirements for achieving this ambitious timeline. It provides structured insights into international coordination and preparedness infrastructure needs.

Key Points

•Surveys expert opinion on the 100 Days Mission goal of developing medical countermeasures within 100 days of a pandemic threat declaration.
•Identifies key bottlenecks including regulatory coordination, manufacturing capacity, and data-sharing infrastructure across nations.
•Highlights governance and international coordination challenges as critical barriers to achieving the 100-day timeline.
•Provides evidence-based recommendations for strengthening global health security frameworks and pandemic preparedness systems.
•Relevant to biosecurity and catastrophic risk reduction efforts that intersect with AI-assisted pandemic response planning.

Cited by 1 page

Page	Type	Quality
Coalition for Epidemic Preparedness Innovations	Organization	53.0

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Frontiers | Pandemic preparedness and response: a survey among experts from high- and low-middle-income countries about the “100 Days Mission” 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 ORIGINAL RESEARCH article

 Front. Public Health , 05 September 2025 

 Sec. Infectious Diseases: Epidemiology and Prevention

 Volume 13 - 2025 | https://doi.org/10.3389/fpubh.2025.1617066 

 Published in Frontiers in Public Health 

 Infectious Diseases: Epidemiology and Prevention

 
 3.4 impact factor
 5.5 citescore
 Part of a Research Topic

 Pandemic Preparedness in Vaccine Safety and Regulation

 26k views
 10 articles
 Editor & Reviewers

 Edited by

 F V Florence Van Hunsel

 Reviewed by

 E C Eustachio Cuscianna

 E P Edmond Puca

 Outline 

 Figures and Tables Figure 1

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 Table 1

 Main technical challenges to the 100DM innovations. 

 View in article 
 ORIGINAL RESEARCH article

 Front. Public Health , 05 September 2025 

 Sec. Infectious Diseases: Epidemiology and Prevention

 Volume 13 - 2025 | https://doi.org/10.3389/fpubh.2025.1617066 

 Pandemic preparedness and response: a survey among experts from high- and low-middle-income countries about the “100 Days Mission” 

 V P Vanessa Pencelli 1 * 

 
 R C Ralf Clemens 1 

 
 M A Mihai Alexandru Bica 1 

 
 S A Sue Ann Costa Clemens 1,2 

 
 
 1. Institute of Global Health, University of Siena, Siena, Italy

 2. Department of Pediatrics, Oxford University, Oxford, United Kingdom

 Article metrics 

 View details Abstract

 Background: 

 The “100 Days Mission” (100DM), designed by the Coalition for Epidemic Preparedness Innovations (CEPI), represents an ambitious new concept in vaccine development for effective pandemic preparedness, rapid response, and the reduction of health inequalities. We aimed to identify potential obstacles to the success of the 100DM by conducting a survey among experts in vaccinology and public health from both high-income countries (HICs) and low- and middle-income countries (LMICs).

 Materials and methods: 

 A descriptive cross-sectional study was conducted, using a semi-structured online survey distributed to 116 experts from both LMICs and HICs. The data collected were analyzed quantitatively and qualitatively, highlighting the differences in responses between the LMICs and HICs respondents.

 Results: 

 The overall response rate was 73.2% (85/116), with 74% (57/77) of the respondents from HICs and 69.2% (27/39) from LMICs. The LMIC respondents (14/27, 51.9%) were more confident in the success of the 100DM than the HIC respondents (15/57, 26.3%). Additionally, LMIC respondents believed more strongly in the potential impact to overcome inequalities (15/27, 55.6% vs. 19/57, 33.3%). Almost all experts from both LMICs and 

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Resource ID: 0e9fa7df4f865beb | Stable ID: ZGE5NWVmNT