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Annual Letter - Chan Zuckerberg Initiative
webchanzuckerberg.com·chanzuckerberg.com/about/annual-letter/
CZI is a major philanthropic funder of AI-for-science initiatives; its annual letters reflect how large tech-aligned philanthropy frames AI's societal role, relevant as context for AI governance and deployment discussions.
Metadata
Importance: 18/100organizational reporthomepage
Summary
The Chan Zuckerberg Initiative's annual letters archive documents CZI's yearly progress toward their mission of curing diseases, improving education, and strengthening communities. Letters highlight how AI and technology investments are increasingly central to their biomedical and educational work, including a decade retrospective on long-term philanthropic bets.
Key Points
- •CZI was founded in 2015 with a pledge to give 99% of Zuckerberg's Meta shares to advance science, education, and community equity.
- •Recent letters (2023–2025) emphasize AI's growing role in biomedical research and education tools.
- •The 2025 letter celebrates 10 years of sustained investment with emerging breakthroughs in science and education.
- •CZI frames its approach as long-term, collaborative 'bold bets' rather than short-term philanthropic grants.
- •AI is positioned as a transformative tool for unlocking scientific discoveries toward curing all diseases by end of century.
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| Page | Type | Quality |
|---|---|---|
| Chan Zuckerberg Initiative | Organization | 50.0 |
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2024 Year in Review: How AI Shaped a Year of Impact [Read More](https://chanzuckerberg.com/blog/2024-look-back/)
# Annual Letters
Chan Zuckerberg Initiative
In 2015, with the birth of their first daughter, Mark Zuckerberg and Priscilla Chan wrote a letter about the world they hoped she and all children would grow up in. In that letter, they also shared their plans to give 99% of their Meta (formerly Facebook) shares to help make that world a reality. Each year, the Chan Zuckerberg Initiative shares the lessons, milestones and impact of CZI’s work.
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2025 **Celebrating 10 Years of Bold Bets and Big Breakthroughs** \\
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We’re highlighting a decade of bold bets across science, education and local communities — and the breakthroughs now emerging from sustained, long-term investment.](https://chanzuckerberg.com/blog/10-year-look-back) [\\
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2024 **How AI Shaped a Year of Impact at CZI** \\
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Discover how advances in AI are transforming biomedical research and enhancing education tools alongside our efforts to support communities and drive progress across our work.](https://chanzuckerberg.com/blog/2024-look-back/) [\\
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2023 **Building for This Moment** \\
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Learn how we’re building for this moment. Our earliest bets in science paved the way for us to use artificial intelligence to unlock new scientific discoveries that will help cure, prevent, or manage all diseases by the end of this century. We also highlight the impact of our education work and share how we’re exploring new ways to leverage our grantmaking and technology capabilities to co-build tools with partners.](https://chanzuckerberg.com/about/annual-letter/year-2023/) [\\
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2022 **A Community of Builders** \\
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We are a community of builders. This community builds many things, from technologies to partnerships. We all share a deep motivation to learn, create and iterate together — because building collaboratively will help us unlock a better future.](https://chanzuckerberg.com/about/annual-letter/year-2022/) [Resource ID:
582fc4234fef03ba | Stable ID: ZGRjNjI2OT