Annual Letter - Chan Zuckerberg Initiative
webCZI is a major philanthropic funder of AI-for-science initiatives; its annual letters reflect how large tech-aligned philanthropy frames AI's societal role, relevant as context for AI governance and deployment discussions.
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Summary
The Chan Zuckerberg Initiative's annual letters archive documents CZI's yearly progress toward their mission of curing diseases, improving education, and strengthening communities. Letters highlight how AI and technology investments are increasingly central to their biomedical and educational work, including a decade retrospective on long-term philanthropic bets.
Key Points
- •CZI was founded in 2015 with a pledge to give 99% of Zuckerberg's Meta shares to advance science, education, and community equity.
- •Recent letters (2023–2025) emphasize AI's growing role in biomedical research and education tools.
- •The 2025 letter celebrates 10 years of sustained investment with emerging breakthroughs in science and education.
- •CZI frames its approach as long-term, collaborative 'bold bets' rather than short-term philanthropic grants.
- •AI is positioned as a transformative tool for unlocking scientific discoveries toward curing all diseases by end of century.
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| Page | Type | Quality |
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| Chan Zuckerberg Initiative | Organization | 50.0 |
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Annual Letters - Chan Zuckerberg Initiative
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2024 Year in Review: How AI Shaped a Year of Impact
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Annual Letters
Chan Zuckerberg Initiative
In 2015, with the birth of their first daughter, Mark Zuckerberg and Priscilla Chan wrote a letter about the world they hoped she and all children would grow up in. In that letter, they also shared their plans to give 99% of their Meta (formerly Facebook) shares to help make that world a reality. Each year, the Chan Zuckerberg Initiative shares the lessons, milestones and impact of CZI’s work.
2025
Celebrating 10 Years of Bold Bets and Big Breakthroughs
We’re highlighting a decade of bold bets across science, education and local communities — and the breakthroughs now emerging from sustained, long-term investment.
2024
How AI Shaped a Year of Impact at CZI
Discover how advances in AI are transforming biomedical research and enhancing education tools alongside our efforts to support communities and drive progress across our work.
2023
Building for This Moment
Learn how we’re building for this moment. Our earliest bets in science paved the way for us to use artificial intelligence to unlock new scientific discoveries that will help cure, prevent, or manage all diseases by the end of this century. We also highlight the impact of our education work and share how we’re exploring new ways to leverage our grantmaking and technology capabilities to co-build tools with partners.
2022
A Community of Builders
We are a community of builders. This community builds many things, from technologies to partnerships. We all share a deep motivation to learn, create and iterate together — because building collaboratively will help us unlock a better future.
2021
Building For the Future
We’ve been learning from our partners and working alongside them to build for breakthroughs, empowerment, and equity with new tools and collaborations. Now we’re ready to double down on our commitments that are showing the greatest potential to make an outsized impact — and accelerate progress toward a healthier, more equitable future.
2020
What We’re Learning
Our CZI journey began five years ago, and this year especially — amidst the tremendous challenges facing our communities, from the longstanding inequities caused by systemic racism to new hardships inflicted by a global pandemic and economic crisis, we feel the urgent call to accelerate change. This year we reflect on our major milestones, how we can affect change together, and the lessons we’re learning along the way.
2019
The Promise of Family
From the very beginning, CZI was rooted in family. It started with us and it’s grown to include hundreds of employees and partners around the world. Meet a few members of our CZI fami
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