AI drives dramatic expansion of Chan Zuckerberg Initiative's funding to 'end all diseases' - Science.org
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Reports on Chan Zuckerberg Initiative's strategic shift toward biomedical AI research with massive funding, relevant to understanding how AI capabilities and resources are being directed in high-stakes domains like disease research.
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The Chan Zuckerberg Initiative (CZI), founded by Priscilla Chan and Mark Zuckerberg with a pledge of over $200 billion, is dramatically expanding its focus on biomedical research and artificial intelligence to achieve its goal of curing, preventing, or managing every disease by the end of the century. As the foundation enters its second decade, it has wound down support for social causes and education to concentrate almost exclusively on science, positioning itself to potentially become the largest biomedical philanthropy in the world. The initiative is leveraging AI as a key tool to accelerate scientific discovery, with Priscilla Chan emphasizing the urgency to achieve their ambitious health goals faster.
Cited by 1 page
| Page | Type | Quality |
|---|---|---|
| Chan Zuckerberg Initiative | Organization | 50.0 |
5 FactBase facts citing this source
| Entity | Property | Value | As Of |
|---|---|---|---|
| Chan Zuckerberg Initiative | Total Funding Raised | 10000000000 | 2025 |
| Chan Zuckerberg Initiative | Total Funding Raised | 4000000000-4500000000 | 2025 |
| Chan Zuckerberg Initiative | Infrastructure Investment | 10000 | 2025 |
| Chan Zuckerberg Initiative | Total Funding Raised | 3500000000 | 2025 |
| Chan Zuckerberg Initiative | GPU Count | 10,000 | 2025 |
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# AI drives dramatic expansion of Chan Zuckerberg Initiative’s funding to end all diseases
## Entering its second decade, philanthropy with Facebook fortune has shed social causes and now focuses on ambitious science dream
- 6 Nov 2025
- 9:30 AM ET
- By [Jon Cohen](https://www.science.org/content/author/jon-cohen "Jon Cohen")
Biologist Cori Bargmann (left) helped launch Priscilla Chan (right) and Mark Zuckerberg’s science philanthropy.Dale Ramos
[Table of contents](https://www.science.org/toc/science/390/6773)
A version of this story appeared in Science, Vol 390, Issue 6773. [Download PDF](https://www.science.org/doi/epdf/10.1126/science.aed6534 "")
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As the promise of artificial intelligence (AI) captivates biomedicine, few people are riding the wave like Priscilla Chan—because few people have her resources. Trained as a pediatrician, Chan and her husband, Facebook creator Mark Zuckerberg, co-run a philanthropy that [launched in 2015](https://www.science.org/content/article/qa-can-facebook-billions-stop-disease-neuroscientist-aims-find-out) with the wildly ambitious—some would say quixotic—goal of curing, preventing, or managing every disease by the end of the century. The couple [pledged](https://www.facebook.com/notes/770757020443898/) nearly their entire fortune—$45 billion then and more than $200 billion today—to the Chan Zuckerberg Initiative (CZI), which would also support their education and progressive causes.
Recently, however, the foundation has wound down support for almost everything but science. And this week, CZI announced it is increasing its research spending, doubling down on AI, and vowing to meet Chan and Zuckerberg’s biomedical goal even earlier—although CZI won’t set a specific target. “As I get older, the faster I personally
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