Yale University School of Medicine — Vascular Therapy Research

[Human Health and Wellbeing] Grant investigators: Chris Somerville and Heather Youngs This page was reviewed but not written by the grant investigators. Yale University staff also reviewed this page prior to publication. The Open Philanthropy Project recommended a grant of $180,000 to the Yale University School of Medicine to support research on the modification of vascular permeability by monoclonal antibodies against key regulatory proteins. Increased permeability might allow medicines to cross the blood-brain barrier and could accelerate the development of new therapies for neurodegenerative diseases such as Alzheimer's Disease, while decreased permeability could be useful in treating conditions such as swelling in stroke victims and sepsis. This discretionary grant falls within our work on scientific research, and specifically within our interest in advancing human health and wellbeing.