International Vaccine Institute — Cholera Vaccine Phase II Trial

[Human Health and Wellbeing] Open Philanthropy recommended a grant of $6,600,000 to the International Vaccine Institute to support a Phase II dose de-escalation trial of a novel cholera vaccine. The trial will test the vaccine's efficacy in children as young as 1 year old. Unlike current vaccines, this new formulation shows promise for high effectiveness in very young children. This grant follows a successful Phase I trial in adults aged 19-45 years. This follows our January 2022 support and falls within our focus area of scientific research, specifically within our interest in advancing human health and wellbeing.